Marijuana or hemp are some of the names used to refer to different varieties of the Cannabis Sativa. This plant, cultivated by multiple societies for thousands of years, has been a source of food, textile fiber, mystical experiences, and medicines.

Its great particularity is the contribution of molecules called cannabinoids, which act on the endocannabinoid system present in all mammals. This system is involved in multitude of physiological processes, and is regulated by different receptors (detail).

Our body produces its own cannabinoids, but it also responds to external cannabinoids, such as those in marijuana. These compounds modulate aspects as varied as the appetite, memory, pain, or nausea, hence the diversity of effects of this plant.

The main cannabinoids in marijuana

Cannabis has dozens of cannabinoids (detail), but mainly two have been studied:

  • THC: it is the main psychoactive component of cannabis, the cause of high. It is the most fun, but also the most dangerous.
  • CBD: regulates the effects of THC, enhancing the good and mitigating the bad (study). In fact CBD is antipsychotic (study, study).

The effect of each variety of marijuana will therefore depend on its contribution of these cannabinoids, and it seems that the demand as a recreational drug has favored variants increasingly rich in THC and poorer in CBD (detail), increasing its power but reducing its benefits.

Evolution of THC and CBD content (in California). Detail:

Note: The variants used for tissues and food are very low in THC, and from them, for example, hemp protein is obtained.

exist synergies between the different compounds in marijuana (detail), being interesting to study the whole plant. However, its legal status makes these investigations difficult, and we will focus on the impact of each of its cannabinoids.

THC benefits

THC (tetrahydrocannabinol) is mainly responsible for the effects that we associate with marijuana: euphoria, loss of coordination, reduced memory and, in most cases, hunger.

Is marijuana therefore fattening? It is a complicated relationship.

This study concludes that obesity is reduced in places where marijuana is legalized. Many other studies find fewer overweight and metabolic problems among consumers of this plant (study, study, study, study, study).

But before concluding that marijuana is a fat-burning supplement, remember that correlation does not imply causation, and there is probably another explanation.

According to this study, marijuana tends to reduce alcohol consumption, which generally fulfills the same recreational function but with many more calories. What’s more, your risk of addiction is lower (study).

Is marijuana hungry?

Beyond these typical observational confounders, clinical trials confirm that marijuana increases caloric intake (study, study). In a world flooded with ultra-processed foods this is bad, but not in all cases, and for example THC has been used with success in diseases that cause dangerous weight loss, such as anorexia, AIDS, or cancer (study, study).

Similarly, a generally detrimental impact of THC, such as memory inhibition (study, review), could become a desired effect in the case of people with posttraumatic stress, where forgetting might help (study, study).

Perhaps the best known benefit of THC has to do with improving the glaucoma, by reducing intraocular pressure (study, study, study). It achieves this effect by dilation of the ocular capillaries, explaining another known symptom among its consumers: red eyes.

In summary, THC has therapeutic potential but in very specific cases, and the associated risks mean that it must be used with care.

For these reasons I am more interested in CBD, with broader applications and minimal risk.

CBD benefits

CBD (cannabidiol) is a complex molecule that interacts with our body through multiple mechanisms, not fully known (detail). It acts as an adaptogen and modulator of different processes, hence the diversity of its effects (detail).

Mechanisms of action of the CBD. Source:

Pain reduction

There are references to the use of cannabis against pain from the year 2,900 BC. C. (detail), and recent studies show its effect (study, study):

  • Several studies in rats conclude that CBD can reduce pain after an operation (study, study, study).
  • A legal drug in Spain (Sativex), with CBD and THC extract, reduces pain and other negative symptoms in people with multiple sclerosis (study, study) and rheumatoid arthritis (study).
  • CBD is also being studied to treat migraines (detail).
Mechanisms of action of marijuana on pain. Source:

CBD is much safer than opioid drugs (study) and, as we will see shortly, it could help reduce its abuse.

Treat anxiety and depression

Traditional antidepressants have dubious medium-term efficacy and many side effects (detail), hence the importance of evaluating alternatives such as CBD.

Studies in animals show positive effects (study, study), and although the evidence in humans is scarce (review), it could help reduce anxiety disorders (study and social phobia (study).

Neuroprotective role

The effect of marijuana in different neurological disorders is being investigated, and the results are promising in some cases (review):

  • Reduces the frequency and intensity of epileptic attacks in children (study, study, study).
  • It could improve the quality of life in patients with Parkinson’s (study, report). Animal studies indicate that the benefits are mediated by a reduction in brain inflammation and a stimulatory effect on neurogenesis (study, study).

Fight addiction

As it does not produce psychoactive effects, CBD is not addictive, and in fact it could help fight drug or alcohol addictions (revision).

The first studies were done on rats, which when taking CBD showed less interest in drugs (study, study).

A study in smokers found that the CBD-treated group subsequently smoked a 40% less than the group given a placebo.

One of the causes of mortality that is growing the most today is opioid pain reliever overdose, and the legalization of marijuana could combat this plague (study, study, study).

Opioid pain relievers are much more dangerous than marijuana. Source:


Cannabis appears to mitigate the symptoms associated with chemotherapy, reducing nausea, vomiting and pain (study, study).

Also, it seems enhance the effectiveness of different drugs and treatments against cancer, but the studies are still preliminary and in animal models (study, study, study, study).

Forms of consumption

There are multiple ways to take CBD, but three stand out:

  1. Inhalation. Using for example a vaporizer. The effect comes fast but goes away soon. Although it is much less dangerous than tobacco, some doubt that it is harmless to the lungs.
  2. Sublingual. Placing drops of CBD oil under the tongue (example). The oral mucosa is rich in capillaries that will produce rapid absorption.
  3. Intake. Including CBD in different recipes (examples). The effect is slower but longer lasting.

Studies use highly variable doses, from 20 to 2000 mg, even if it is not recommended to exceed 600 mg (detail). If you want to experiment, start with small doses.

If you want to try a good CBD oil, I recommend WeBotanix (you will have a discount with the code FR10).

Marijuana Risks

Like its effects, the risks vary according to quality and composition. For starters, marijuana presents risk of addiction, but much lower than legal substances such as tobacco or alcohol (study).

There is also some risk of neurological damage (study) and of schizophrenia in people with genetic predisposition (study). These risks are primarily mediated by THC, and in fact CBD is associated with lower risk of schizophrenia (study).

The risk is increased when consuming marijuana before completing brain development, hence it should be avoided in the case of adolescents (detail).

The CBD isolate, Conversely, is well tolerated and presents few risks, as recognized by the WHO itself (detail). That being said, it could interact with some drugs, so be careful if you are medicated (detail).


Different compounds in cannabis produce different effects, and CBD appears to present the best benefit / risk profile.

If we already refer to marijuana, the criteria for defining which drugs are legal and which are not many times more political than scientific. For decades the dangers of marijuana have been exaggerated while its potential benefits have been ignored.

With that said, let’s not forget that our ancestors treated these plants with respect, and we must follow their example. The evidence is still scant and its abuse as a recreational drug carries risks, especially among the very young.

Used strategically It can be a powerful tool, but depending on it to have fun or escape our problems is a bad idea. Evading reality will not improve it. Facing it with mental clarity yes.